Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

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Introduction.There is a growing body of evidence Lotion for the role of vitamin K in cardiovascular health.As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification.However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors.Material and Methods.

We performed a pilot cross-sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people.The concentration of protein induced by vitamin K absence-II (PIVKA-II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA.Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results.Twenty-three healthy subjects were enrolled (16 female; mean age 21.

3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2).The diastolic blood pressure (DBP) was lower in vitamin K-deficient subjects (58 ± 9 vs.

67 ± 5 mmHg, p = 0.01).The mean arterial blood pressure also differed (75 ± 9 vs.83 ± 6, p = 0.02).

PIVKA-II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ? PURE LEMON JUICE ns.).Stepwise regression identified PIVKA-II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.

1%; PIVKA-II: ß = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p��< 0.

05).Conclusions.The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.